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Chromium polynicotinate and weight loss11/30/2023 ![]() ![]() Exercise effects on chromium excretion of trained and untrained men consuming a constant diet. Metabolism 2002 51: 589–94Īnderson RA, Bryden NA, Polansky MM, et al. Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body weight in dexamethasone-treated rats. Chromium homeostasis in patients with type II (NIDDM) diabetes. Morris BW, MacNeil S, Hardisty CA, et al. Effects of diets high in simple sugars on urinary chromium losses. The inter-relationship between insulin and chromium in hyperinsulinaemic euglycaemic clamps in healthy volunteers. Dietary and metabolite effects on trivalent chromium retention and distribution in rats. Am J Clin Nutr 1985 41: 1177–83Īnderson RA, Polansky MM. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Nutrition 1995 11 (1 Suppl.): 83–6Īnderson RA, Kozlovsky AS. Chromium improves insulin response to glucose in rats. Striffler JS, Law JS, Polansky MM, et al. Is chromium a trace essential metal? Biofactors 2000 11: 149–62 The bioinorganic chemistry of chromium(III). Potential neurological effects (both beneficial and deleterious) from Cr(pic) 3 supplementation require further study. Given that in vitro studies suggest that other forms of chromium used as nutritional supplements, such as chromium chloride, are unlikely to be susceptible to generating this type of oxidative damage, the use of these compounds, rather than Cr(pic) 3, would appear warranted. Recent cell culture and in vivo rat studies have indicated that Cr(pic) 3 probably generates oxidative damage of DNA and lipids and is mutagenic, although the significance of these results on humans taking the supplement for prolonged periods of time is unknown and should be a focus for future investigations. ![]() However, over a decade of human studies with Cr(pic) 3 indicate that the supplement has not demonstrated effects on the body composition of healthy individuals, even when taken in combination with an exercise training programme. Additionally, claims have appeared that the supplement might give rise to deleterious effects. ![]() Cr(pic) 3 has been amazingly popular with the general public, especially with athletes who may have exercise-induced increased urinary chromium loss however, its effectiveness in manifesting body composition changes has been an area of intense debate in the last decade. Because the supplement is absorbed better than dietary chromium, most studies have focused on the use of chromium picolinate. As this role probably involves potentiation of insulin signalling, chromium dietary supplementation has been postulated to potentially have effects on body composition, including reducing fat mass and increasing lean body mass. The element chromium apparently has a role in maintaining proper carbohydrate and lipid metabolism in mammals. ![]()
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